Chest involvement by multiple myeloma is typically associated with what?

Chest involvement by multiple myeloma is typically associated with what?

• A. Localized Osteoblastic Sclerosis
• B. Metastatic Disease
• C. Pneumothorax
• D. Calcified Nodules

Answer: (B)

Multiple myeloma causes osteolytic destruction of bone due to clonal plasma cells activating osteoclasts. When the chest is affected, imaging typically shows lytic lesions in thoracic bones such as the ribs, sternum, or clavicles, which resemble metastatic bone disease. This pattern contrasts with osteoblastic sclerosis (seen with some prostate or breast metastases), pneumothorax (air in the pleural space), or calcified nodules (often granulomatous or healed infections). Therefore, chest involvement by multiple myeloma is best described as metastatic-type bone disease.

Multiple myeloma causes osteolytic destruction of bone due to clonal plasma cells activating osteoclasts. When the chest is affected, imaging typically shows lytic lesions in thoracic bones such as the ribs, sternum, or clavicles, which resemble metastatic bone disease. This pattern contrasts with osteoblastic sclerosis (seen with some prostate or breast metastases), pneumothorax (air in the pleural space), or calcified nodules (often granulomatous or healed infections). Therefore, chest involvement by multiple myeloma is best described as metastatic-type bone disease.