Which of the following are subtypes of non-small cell lung cancer?

Which of the following are subtypes of non-small cell lung cancer?

• A. Squamous cell carcinoma
• B. Adenocarcinoma
• C. Large cell carcinoma
• D. All of the above

Answer: (D)

Non-small cell lung cancer comprises several histologic subtypes distinct from small cell lung cancer. The main NSCLC subtypes are squamous cell carcinoma, which often arises in the central airways and is strongly linked to smoking; adenocarcinoma, the most common NSCLC, typically arising peripherally and more common in nonsmokers; and large cell carcinoma, a poorly differentiated NSCLC category when no specific features of the other two are identified. These categories are used to describe the tumor's microscopic appearance and guide treatment decisions. Since all three listed entities are recognized NSCLC subtypes, the correct choice is that all of the above.

Non-small cell lung cancer comprises several histologic subtypes distinct from small cell lung cancer. The main NSCLC subtypes are squamous cell carcinoma, which often arises in the central airways and is strongly linked to smoking; adenocarcinoma, the most common NSCLC, typically arising peripherally and more common in nonsmokers; and large cell carcinoma, a poorly differentiated NSCLC category when no specific features of the other two are identified. These categories are used to describe the tumor's microscopic appearance and guide treatment decisions. Since all three listed entities are recognized NSCLC subtypes, the correct choice is that all of the above.